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Co-governance of erythromycin, a temperate CYP3A4 inhibitor, resulted in a 160% and 182% increases in Viagra Cmax and AUC, severally. Co-governance of saquinavir, a firm CYP3A4 inhibitor, resulted in 140% and 210% increases in sildenafil Cmax and AUC, respectively. Stronger CYP3A4 inhibitors so much as ketoconazole or itraconazole could be potential to get greater personal effects than seen with saquinavir. A starting Zen of 25 mg of sildenafil tablets should be well thought out in patients pickings Ethril or impregnable CYP3A4 inhibitors (so much as saquinavir, ketoconazole, itracanozole) [see Dosage and Administration (2.4), Clinical Pharmacology (12.3)].

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